硫酸葡聚醣(Dextran sulfate sodium, DSS)是帶負電荷的硫酸化葡聚醣，分子量為40000Da。硫酸葡聚醣(Dextran sulfate sodium, DSS)廣泛用於在小鼠模型中誘導結腸炎。當硫酸葡聚醣(Dextran sulfate sodium, DSS)在飲用水中口服給藥時，誘發腸道炎症(induce colitis)。使用2％至5％的濃度，在一周內出現症狀。
TdB Consultancy 自從1980年就開始銷售DSS，有豐富的製作技術，產品也廣泛的使用在許多結腸炎研究中。
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138. Te Velde, A. A. et al. Effects of Dietary Plant Sterols and Stanol Esters with Low- and High-Fat Diets in Chronic and Acute Models for Experimental Colitis. Nutrients 7, 8518–8531 (2015).
139. Zhdanov, A. V., Okkelman, I. A., Collins, F. W. J., Melgar, S. & Papkovsky, D. B. A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression. Biochim. Biophys. Acta BBA – Bioenerg. 1847, 1254–1266 (2015).
140. Speca, S. et al. Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis. Inflamm. Bowel Dis. 22, 279–292 (2016).
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SELECTED OLDER PUBLICATIONS
143. Sommer, F. et al. Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture. PLOS ONE 9, e85254 (2014).
144. Wagner, A. E. et al. DSS-induced acute colitis in C57BL/6 mice is mitigated by sulforaphane pre-treatment. J. Nutr. Biochem. 24, 2085–2091 (2013).
145. Beloqui, A. et al. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. Int. J. Pharm. 454, 775–783 (2013).
146. Thaker, A. I., Shaker, A., Rao, M. S. & Ciorba, M. A. Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS). JoVE J. Vis. Exp. e4100 (2012). doi:10.3791/410
147. Van Crombruggen, K. et al. Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis. Eur. J. Pharmacol. 579, 337–349 (2008).
148. Ten Hove, T., Drillenburg, P., Wijnholds, J., te Velde, A. A. & van Deventer, S. J. H. Differential Susceptibility of Multidrug Resistance Protein-1 Deficient Mice to DSS and TNBS-Induced Colitis. Dig. Dis. Sci. 47, 2056–2063 (2002).
149. Dieleman et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 114, 385–391 (1998).