TdB dextran sulfates sodium

TdB Dextran sulfate sodium – DSS Colitis 葡聚糖硫酸

CAS no. 9011-18-1​
Mw : 40000 Da 50g , 100g , 500g​

brands logo TdB Labs
分類: 標籤: , 產品品牌:
原廠介紹
結腸炎研究的黃金標準。炎症性腸病是一種病因不明的多因素疾病，由兩種主要亞型組成，即潰瘍性結腸炎(ulcerative colitis)和克羅恩病(Crohn’s disease)。硫酸葡聚醣(Dextran sulfate sodium, DSS)用於誘導動物的結腸炎的實驗。改變硫酸葡聚醣(Dextran sulfate sodium, DSS)的濃度或劑量的周期可以容易地誘發急性，慢性或複發性結腸炎。

什麼是硫酸葡聚醣(Dextran sulfate sodium, DSS)？

硫酸葡聚醣(Dextran sulfate sodium, DSS)是帶負電荷的硫酸化葡聚醣，分子量為40000Da。硫酸葡聚醣(Dextran sulfate sodium, DSS)廣泛用於在小鼠模型中誘導結腸炎。當硫酸葡聚醣(Dextran sulfate sodium, DSS)在飲用水中口服給藥時，誘發腸道炎症(induce colitis)。使用2％至5％的濃度，在一周內出現症狀。

normal tissue正常的老鼠腸組織​
tissue with dss使用DSS誘導的腸組織​使用3% DSS於飲用水中，作用7天。​
如果您需要更大量的硫酸葡聚醣(Dextran sulfate sodium, DSS)，請立即聯絡我們取得報價。

參考文獻

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  61. Sommer, F. et al. Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture. PLOS ONE 9, e85254 (2014).
  62. Silva, Z. E. V. da, Lehr, H.-A. & Velin, D. In vitro and in vivo Repair Activities of Undifferentiated and Classically and Alternatively Activated Macrophages. PAT 81, 86–93 (2014).
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  65. Judd, L. M. et al. TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow. American Journal of Physiology-Gastrointestinal and Liver Physiology 308, G12–G24 (2014).
  66. Jakobsson, T. et al. The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice. Mucosal Immunology 7, 1416–1428 (2014).
  67. Wagner, A. E. et al. DSS-induced acute colitis in C57BL/6 mice is mitigated by sulforaphane pre-treatment. The Journal of Nutritional Biochemistry 24, 2085–2091 (2013).
  68. Thaker, A. I. et al. IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice. Gastroenterology 145, 416-425.e4 (2013).
  69. Schreiber, O. et al. iNOS-Dependent Increase in Colonic Mucus Thickness in DSS-Colitic Rats. PLOS ONE 8, e71843 (2013).
  70. Ranganathan, P., Jayakumar, C., Santhakumar, M. & Ramesh, G. Netrin-1 regulates colon-kidney cross talk through suppression of IL-6 function in a mouse model of DSS-colitis. American Journal of Physiology-Renal Physiology 304, F1187–F1197 (2013).
  71. Konieczna, P. et al. Immunomodulation by Bifidobacterium infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid-Dependent and Independent Mechanisms. PLOS ONE 8, e62617 (2013).
  72. Konieczna, P. et al. Immunomodulation by Bifidobacterium infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid-Dependent and Independent Mechanisms. PLOS ONE 8, e62617 (2013).
  73. Hall, L. J. et al. Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. Mucosal Immunology 6, 1016–1026 (2013).
  74. Guzman, J. R. et al. Oxymatrine Prevents NF-κB Nuclear Translocation And Ameliorates Acute Intestinal Inflammation. Scientific Reports 3, 1629 (2013).
  75. Brounais-Le Royer, B. et al. Effects of an Interleukin-15 Antagonist on Systemic and Skeletal Alterations in Mice with DSS-Induced Colitis. The American Journal of Pathology 182, 2155–2167 (2013).
  76. Beloqui, A. et al. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. International Journal of Pharmaceutics 454, 775–783 (2013).
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  78. Øines, E., Murison, R., Mrdalj, J., Grønli, J. & Milde, A. M. Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. Physiology & Behavior 105, 1058–1066 (2012).
  79. Xu, C., Shen, Y., Littman, D. R., Dustin, M. L. & Velázquez, P. Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. Journal of Leukocyte Biology 92, 413–419 (2012).
  80. Wadie, W. et al. STW 5 is effective in dextran sulfate sodium-induced colitis in rats. Int J Colorectal Dis 27, 1445–1453 (2012).
  81. Thaker, A. I., Shaker, A., Rao, M. S. & Ciorba, M. A. Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp (2012). doi:10.3791/4100
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  84. Spadoni, I., Iliev, I. D., Rossi, G. & Rescigno, M. Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis. Mucosal Immunology 5, 184–193 (2012).
  85. Rang, S. et al. Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction. ERA (2012). doi:10.7939/R3DJ58W4W
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2011-2000

  1. Villegas, I., Sánchez‐Fidalgo, S. & Lastra, C. A. de la. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Molecular Nutrition & Food Research 55, 259–267 (2011).
  2. Rahman, A. et al. Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells. Clinical & Experimental Immunology 163, 123–130 (2011).
  3. Queiroz, K. C. S. et al. Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis. Mol Med 17, 1119–1126 (2011).
  4. Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. PNAS 108, 9601–9606 (2011).
  5. Lenoir, L. et al. Lemon Verbena Infusion Consumption Attenuates Oxidative Stress in Dextran Sulfate Sodium-Induced Colitis in the Rat. Dig Dis Sci 56, 3534–3545 (2011).
  6. Hall, L. J. et al. Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis. Dig Dis Sci 56, 79–89 (2011).
  7. Deboer, M. D. & Li, Y. Puberty Is Delayed in Male Mice With Dextran Sodium Sulfate Colitis Out of Proportion to Changes in Food Intake, Body Weight, and Serum Levels of Leptin. Pediatric Research 69, 34–39 (2011).
  8. Cançado, G. G. L. et al. Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice. Inflamm Bowel Dis 17, 2275–2286 (2011).
  9. Banerjee, S. et al. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. American Journal of Physiology-Gastrointestinal and Liver Physiology 300, G273–G282 (2011).
  10. van Dop, W. A. et al. The absence of functional PI3Kγ prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. Immunology Letters 131, 33–39 (2010).
  11. Snoek, S. A. et al. Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. British Journal of Pharmacology 160, 322–333 (2010).
  12. Sina, C. et al. Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB. Inflamm Bowel Dis 16, 320–331 (2010).
  13. Sánchez-Fidalgo, S. et al. Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice. Clinical Nutrition 29, 663–673 (2010).
  14. Petersson, J. et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 300, G327–G333 (2010).
  15. Murphy, C. T. et al. Technical Advance: Function and efficacy of an α4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis. Journal of Leukocyte Biology 88, 1271–1278 (2010).
  16. Murphy, C. T. et al. Technical Advance: Function and efficacy of an α4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis. Journal of Leukocyte Biology 88, 1271–1278 (2010).
  17. Murphy, C. T. et al. Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis. Clinical & Experimental Immunology 162, 188–196 (2010).
  18. Konerding, M. A. et al. Inflammation-Induced Intussusceptive Angiogenesis in Murine Colitis. The Anatomical Record 293, 849–857 (2010).
  19. Johansson, M. E. V. et al. Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model. PLOS ONE 5, e12238 (2010).
  20. Edelson, B. T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. Journal of Experimental Medicine 207, 823–836 (2010).
  21. DeBoer, M. D., Li, Y. & Cohn, S. Colitis causes delay in puberty in female mice out of proportion to changes in leptin and corticosterone. J Gastroenterol 45, 277–284 (2010).
  22. Ciorba, M. A. et al. Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis. The Journal of Immunology 184, 3907–3916 (2010).
  23. Cadwell, K. et al. Virus-Plus-Susceptibility Gene Interaction Determines Crohn’s Disease Gene Atg16L1 Phenotypes in Intestine. Cell 141, 1135–1145 (2010).
  24. Borniquel, S., Jansson, E. Å., Cole, M. P., Freeman, B. A. & Lundberg, J. O. Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease. Free Radical Biology and Medicine 48, 499–505 (2010).
  25. Zheng, L., Riehl, T. E. & Stenson, W. F. Regulation of Colonic Epithelial Repair in Mice by Toll-Like Receptors and Hyaluronic Acid. Gastroenterology 137, 2041–2051 (2009).
  26. Turhan, A. et al. Vascular Microarchitecture of Murine Colitis-Associated Lymphoid Angiogenesis. The Anatomical Record 292, 621–632 (2009).
  27. Tsuda, A. et al. Bimodal Oscillation Frequencies of Blood Flow in the Inflammatory Colon Microcirculation. The Anatomical Record 292, 65–72 (2009).
  28. Sina, C. et al. G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation. The Journal of Immunology 183, 7514–7522 (2009).
  29. Schreiber, O. et al. Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions. American Journal of Physiology-Gastrointestinal and Liver Physiology 296, G534–G542 (2009).
  30. Miele, L. F. et al. Blood Flow Patterns Spatially Associated with Platelet Aggregates in Murine Colitis. The Anatomical Record 292, 1143–1153 (2009).
  31. Lång, P., Lange, S., Delbro, D. & Andersson, G. Induction and cellular expression of tartrate resistant acid phosphatase during dextran sodium sulphate induced colitis in rats. Histochem Cell Biol 132, 599 (2009).
  32. Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M. & Rescigno, M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunology 2, 340–350 (2009).
  33. Huang, T.-Y. et al. Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. Toxicology and Applied Pharmacology 237, 69–82 (2009).
  34. Hansen, J. J., Holt, L. & Sartor, B. R. Gene Expression Patterns in Experimental Colitis in IL-10-Deficient Mice. Inflamm Bowel Dis 15, 890–899 (2009).
  35. Davies, P. S., Powell, A. E., Swain, J. R. & Wong, M. H. Inflammation and Proliferation Act Together to Mediate Intestinal Cell Fusion. PLOS ONE 4, e6530 (2009).
  36. Canevari, M. et al. Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery. International Journal of Pharmaceutics 368, 171–177 (2009).
  37. Banerjee, S. et al. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunol 2, 220–231 (2009).
  38. Voltan, S. et al. Lactobacillus crispatus M247-Derived H2O2 Acts as a Signal Transducing Molecule Activating Peroxisome Proliferator Activated Receptor-γ in the Intestinal Mucosa. Gastroenterology 135, 1216–1227 (2008).
  39. Turhan, A. et al. Bridging Mucosal Vessels Associated with Rhythmically Oscillating Blood Flow in Murine Colitis. The Anatomical Record 291, 74–82 (2008).
  40. Ramakers, J. D., Mensink, R. P., Verstege, M. I., Velde, A. A. te & Plat, J. An arachidonic acid-enriched diet does not result in more colonic inflammation as compared with fish oil- or oleic acid-enriched diets in mice with experimental colitis. British Journal of Nutrition 100, 347–354 (2008).
  41. Melgar, S. et al. Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease. International Immunopharmacology 8, 836–844 (2008).
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  43. Matters, G. L. et al. The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease. Journal of Immunotoxicology 5, 179–187 (2008).
  44. Li, H. et al. Intestinal, adipose, and liver inflammation in diet-induced obese mice. Metabolism 57, 1704–1710 (2008).
  45. Karlsson, A. et al. Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters. International Immunopharmacology 8, 20–27 (2008).
  46. Fritsch Fredin, M. et al. The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis. Pharmacological Research 58, 222–231 (2008).
  47. Spek, A. C., Kate, F. J. W. ten & Velde, A. A. te. Factor V Leiden and the etiology of inflammatory bowel disease. Thromb Haemost 98, 670–673 (2007).
  48. Rigby, R. J., Simmons, J. G., Greenhalgh, C. J., Alexander, W. S. & Lund, P. K. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 26, 4833–4841 (2007).
  49. Ramakers, J. D. et al. The PPARγ Agonist Rosiglitazone Impairs Colonic Inflammation in Mice with Experimental Colitis. J Clin Immunol 27, 275–283 (2007).
  50. Petersson, J. et al. eNOS involved in colitis-induced mucosal blood flow increase. American Journal of Physiology-Gastrointestinal and Liver Physiology 293, G1281–G1287 (2007).
  51. Nysœter, G. et al. Effect of live Salmonella Ty21a in Dextran Sulfate Sodium-induced Colitis. Drug Target�Insights 2, DTI.S220 (2007).
  52. Melgar, S., Gillberg, P.-G., Hockings, P. D. & Olsson, L. E. High-throughput magnetic resonance imaging in murine colonic inflammation. Biochemical and Biophysical Research Communications 355, 1102–1107 (2007).
  53. Melgar, S. et al. Mice with experimental colitis show an altered metabolism with decreased metabolic rate. American Journal of Physiology-Gastrointestinal and Liver Physiology 292, G165–G172 (2007).
  54. Holma, R., Salmenperä, P., Virtanen, I., Vapaatalo, H. & Korpela, R. Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats. J. Physiol. Pharmacol. 58, 455–467 (2007).
  55. Brown, S. L. et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest 117, 258–269 (2007).
  56. Arslan, G. et al. No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats. Integr Med�Insights 2, 117863370700200000 (2007).
  57. Van der Sluis, M. et al. Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection. Gastroenterology 131, 117–129 (2006).
  58. Lundberg, S., Lindholm, J., Lindbom, L., Hellström, P. M. & Werr, J. Integrin α2β1 Regulates Neutrophil Recruitment and Inflammatory Activity in Experimental Colitis in Mice. Inflamm Bowel Dis 12, 172–177 (2006).
  59. Larsson, M. H., Rapp, L. & Lindström, E. Effect of DSS-induced colitis on visceral sensitivity to colorectal distension in mice. Neurogastroenterology & Motility 18, 144–152 (2006).
  60. Larsson, A. E. et al. Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Inflamm Bowel Dis 12, 478–485 (2006).
  61. Giannakis, M. et al. Molecular Properties of Adult Mouse Gastric and Intestinal Epithelial Progenitors in Their Niches. J. Biol. Chem. 281, 11292–11300 (2006).
  62. Chidlow, J. H. et al. Differential Angiogenic Regulation of Experimental Colitis. The American Journal of Pathology 169, 2014–2030 (2006).
  63. Brand, S. et al. IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. American Journal of Physiology-Gastrointestinal and Liver Physiology 290, G827–G838 (2006).
  64. Sund, M. et al. Reduced susceptibility to dextran sulphate sodium-induced colitis in the interleukin-2 heterozygous (IL-2+/–) mouse. Immunology 114, 554–564 (2005).
  65. Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I. & Stappenbeck, T. S. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. PNAS 102, 99–104 (2005).
  66. Milde, A. M., Arslan, G., Overmier, J. B., Berstad, A. & Murison, R. An acute stressor enhances sensitivity to a chemical irritant and increases51CrEDTA permeability of the colon in adult rats. Integr. psych. behav. 40, 35–44 (2005).
  67. Elrod, J. W. et al. DSS-Induced Colitis Is Exacerbated in STAT-6 Knockout Mice. Inflamm Bowel Dis 11, 883–889 (2005).
  68. Castagliuolo, I. et al. Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice. FEMS Immunol Med Microbiol 43, 197–204 (2005).
  69. Brun, P. et al. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology 288, G621–G629 (2005).
  70. Bennink, R. J. et al. Dedicated Pinhole SPECT of Intestinal Neutrophil Recruitment in a Mouse Model of Dextran Sulfate Sodium–Induced Colitis. J Nucl Med 46, 526–531 (2005).
  71. Leemans, J. C. et al. The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense. The Journal of Immunology 172, 1125–1131 (2004).
  72. Edalat, M., Mannervik, B. & Axelsson, L.-G. Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria. Histochem Cell Biol 122, 151–159 (2004).
  73. Bene, L. et al. Partial Protection against Dextran Sodium Sulphate Induced Colitis in Histamine-Deficient, Histidine Decarboxylase Knockout Mice. Journal of Pediatric Gastroenterology and Nutrition 39, 171 (2004).
  74. Sasaki, M. et al. The 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Pravastatin Reduces Disease Activity and Inflammation in Dextran-Sulfate Induced Colitis. J Pharmacol Exp Ther 305, 78–85 (2003).
  75. Sasaki, M. et al. The 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Pravastatin Reduces Disease Activity and Inflammation in Dextran-Sulfate Induced Colitis. J Pharmacol Exp Ther 305, 78–85 (2003).
  76. Sasaki, M. et al. Increased disease activity in eNOS-deficient mice in experimental colitis. Free Radical Biology and Medicine 35, 1679–1687 (2003).
  77. Milde, A. M., Sundberg, H., RØseth, A. G. & Murison, R. Proactive Sensitizing Effects of Acute Stress on Acoustic Startle Responses and Experimentally Induced Colitis in Rats: Relationship to Corticosterone. Stress 6, 49–57 (2003).
  78. Milde, A. M., Sundberg, H., RØseth, A. G. & Murison, R. Proactive Sensitizing Effects of Acute Stress on Acoustic Startle Responses and Experimentally Induced Colitis in Rats: Relationship to Corticosterone. Stress 6, 49–57 (2003).
  79. Börjesson, L. & Delbro, D. S. Neurogenic and non-neurogenic mechanisms in response of rat distal colon muscle to dextran sulphate sodium treatment. Autonomic Neuroscience 107, 74–80 (2003).
  80. Spiik, A.-K. et al. Abrogated lymphocyte infiltration and lowered CD14 in dextran sulfate induced colitis in mice treated with p65 antisense oligonucleotides. Int J Colorectal Dis 17, 223–232 (2002).
  81. Milde, A. M. & Murison, R. A study of the effets of restraint stress on colitis induced by dextran sulphate sodium in singly housed rats. Integrative Physiological & Behavioral Science 37, 140–150 (2002).
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  83. Williams, K. L. et al. Enhanced survival and mucosal repair after dextran sodium sulfate–induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120, 925–937 (2001).
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  85. Börjesson, L., Aldenborg, F. & Delbro, D. S. Functional effects of dextran sulphate sodium (DSS) treatment on the longitudinal muscle of rat distal colon. Journal of Autonomic Pharmacology 21, 121–129 (2001).
  86. Stevceva, L. et al. Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice. Genes Immun 1, 213–218 (2000).
  87. Morteau, O. et al. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J Clin Invest 105, 469–478 (2000).

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