TdB Dextran sulfate sodium – DSS Colitis 葡聚糖硫酸

CAS no. 9011-18-1​
Mw : 40000 Da 50g , 100g , 500g​

TdB Consultancy AB
分類: 產品品牌:
結腸炎研究的黃金標準。炎症性腸病是一種病因不明的多因素疾病,由兩種主要亞型組成,即潰瘍性結腸炎(ulcerative colitis)和克羅恩病(Crohn’s disease)。硫酸葡聚醣(Dextran sulfate sodium, DSS)用於誘導動物的結腸炎的實驗。改變硫酸葡聚醣(Dextran sulfate sodium, DSS)的濃度或劑量的周期可以容易地誘發急性,慢性或複發性結腸炎。

什麼是硫酸葡聚醣(Dextran sulfate sodium, DSS)?

硫酸葡聚醣(Dextran sulfate sodium, DSS)是帶負電荷的硫酸化葡聚醣,分子量為40000Da。硫酸葡聚醣(Dextran sulfate sodium, DSS)廣泛用於在小鼠模型中誘導結腸炎。當硫酸葡聚醣(Dextran sulfate sodium, DSS)在飲用水中口服給藥時,誘發腸道炎症(induce colitis)。使用2%至5%的濃度,在一周內出現症狀。

normal tissue正常的老鼠腸組織​
tissue with dss使用DSS誘導的腸組織​
使用3% DSS於飲用水中,作用7天。​

如果您需要更大量的硫酸葡聚醣(Dextran sulfate sodium, DSS),請立即聯絡我們取得報價。

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TdB Consultancy 自從1980年就開始銷售DSS,有豐富的製作技術,產品也廣泛的使用在許多結腸炎研究中。

以下是2019年的最新發表文獻:

2019

1. Al-Omari, M. M., Razan B. Al-Ghariebeh, A. A. A. A., Zoubi, H. A.- & Al-Qaoud, K. M. Camel milk Whey Inhibits Inflammatory Colorectal Cancer Development Via Down regulation of Pro-inflammatory Cytokines in Induced AOM/DSS Mouse Model. Emir. J. Food Agric. 256–262 (2019). doi:10.9755/ejfa.2019.v31.i4.1935

2. Samba-Mondonga, M., Constante, M., Fragoso, G., Calvé, A. & Santos, M. M. Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet. PLOS ONE 14, e0208677 (2019).

3. Body-Malapel, M. et al. The RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases. Mucosal Immunol. 12, 468 (2019).

4. Cribiù, F. M. et al. Using Robotic Systems to Process and Embed Colonic Murine Samples for Histological Analyses. JoVE J. Vis. Exp. e58654 (2019). doi:10.3791/58654

5. Garibay, D. et al. TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity. Obes. Surg. 29, 1593–1601 (2019).

6. Neil, J. A. et al. IFN-I and IL-22 mediate protective effects of intestinal viral infection. Nat. Microbiol. 1 (2019). doi:10.1038/s41564-019-0470-1

7. Durmus, S. et al. ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation. Arch. Toxicol. 93, 775–790 (2019).

8. Chang, C.-L. et al. Synergistic effect of combined melatonin and adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes on amelioration of dextran sulfate sodium (DSS)-induced acute colitis. 19

9. Casado‐Bedmar, M., Heil, S. D. S., Myrelid, P., Söderholm, J. D. & Keita, Å. V. Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis. Neurogastroenterol. Motil. 31, e13503 (2019).

10. Chang, Y.-L. et al. Therapeutic effects of a single injection of human umbilical mesenchymal stem cells on acute and chronic colitis in mice. Sci. Rep. 9, 5832 (2019).

11. Jofra, T. et al. Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22. Clin. Exp. Immunol.

12. Coburn, L. A. et al. Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene 38, 1067 (2019).

13. Salmenkari, H. et al. The use of unlicensed bone marrow–derived platelet lysate–expanded mesenchymal stromal cells in colitis: a pre-clinical study. Cytotherapy 21, 175–188 (2019).

14. Leleu-Chavain, N. et al. Benzo[d]thiazol 2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties. Eur. J. Med. Chem. 165, 347–362 (2019).

15. Burrello, C. et al. Fecal Microbiota Transplantation Controls Murine Chronic Intestinal Inflammation by Modulating Immune Cell Functions and Gut Microbiota Composition. Cells 8, 517 (2019).

16. Chen, Y., Zhang, M. & Ren, F. A Role of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis. Molecules 24, 513 (2019).

17. Singh, K. et al. Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome. Front. Cell. Infect. Microbiol. 9, (2019).

18. De Vries, L. C. S. et al. A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function. Inflamm. Bowel Dis. 25, 647–660 (2019).

19. Friedrich, M. et al. HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation. Mucosal Immunol. 12, 656 (2019).

20. Staats, S. et al. Dietary ursolic acid improves health span and life span in male Drosophila melanogaster. BioFactors 45, 169–186 (2019).

21. Burrello, C. et al. Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells. Life Sci. Alliance 2, e201800229 (2019).

22. Aden, K. et al. Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. Gastroenterology 156, 145-159.e19 (2019).

23. Gowrikumar, S. et al. Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner. Oncogene 38, 5321 (2019).

24. Dempsey, E., Abautret-Daly, Á., Docherty, N. G., Medina, C. & Harkin, A. Persistent central inflammation and region specific cellular activation accompany depression- and anxiety-like behaviours during the resolution phase of experimental colitis. Brain. Behav. Immun. (2019). doi:10.1016/j.bbi.2019.05.007

2018

25. Markovic, M. et al. Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations. Pharmaceutics 11, 186 (2019).

26. Cribiù, F. M. et al. Implementation of an automated inclusion system for the histological analysis of murine tissue samples: A feasibility study in DSS-induced chronic colitis. Eur. J. Inflamm. 16, 2058739218776883 (2018).

27. Cuellar-Nuñez, M. L. et al. Physicochemical and nutraceutical properties of moringa (Moringa oleifera) leaves and their effects in an in vivo AOM/DSS-induced colorectal carcinogenesis model. Food Res. Int. 105, 159–168 (2018).

28. Fan, T.-J. et al. Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. Inflamm. Bowel Dis. 24, 2394–2403 (2018).

29. Greicius, G. et al. PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proc. Natl. Acad. Sci. 115, E3173–E3181 (2018).

30. Willemze, R. A. et al. Neuronal control of experimental colitis occurs via sympathetic intestinal innervation. Neurogastroenterol. Motil. 30, e13163 (2018).

31. Ducheix, S. et al. Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate. Gastroenterology 155, 1524-1538.e9 (2018).

32. Radulovic, K. et al. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. Mucosal Immunol. 11, 811–819 (2018).

33. Paveljšek, D. et al. Lactobacillus fermentum L930BB and Bifidobacterium animalis subsp. animalis IM386 initiate signalling pathways involved in intestinal epithelial barrier protection. Benef. Microbes 9, 515–525 (2018).

34. Liu, X. et al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int. J. Cancer 143, 1516–1529 (2018).

35. Nikolic, A. et al. Intraperitoneal administration of mesenchymal stem cells ameliorates acute dextran sulfate sodium-induced colitis by suppressing dendritic cells. Biomed. Pharmacother. 100, 426–432 (2018).

36. Beneficial anti-inflammatory effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in the treatment of dextran sulfate sodium-induced colitis in mice. J. Physiol. Pharmacol. (2018). doi:10.26402/jpp.2018.4.07

37. K. Martin, P. et al. Autophagy proteins suppress protective type I interferon signaling in response to the murine gut microbiota. Nat. Microbiol. 3, (2018).

38. Sferra, R. et al. Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study. Eur. J. Histochem. EJH 62, (2018).

39. Messal, N. et al. Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. Biochim. Biophys. Acta BBA – Mol. Basis Dis. 1864, 3618–3628 (2018).

40. Cardoso, A. et al. The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis. Front. Immunol. 9, (2018).

41. Darnaud, M. et al. Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis. Gastroenterology 154, 1009-1023.e14 (2018).

42. Burrello, C. et al. Short-term Oral Antibiotics Treatment Promotes Inflammatory Activation of Colonic Invariant Natural Killer T and Conventional CD4+ T Cells. Front. Med. 5, (2018).

43. Gobert, A. P. et al. Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front. Immunol. 9, (2018).

44. Ajayi, B., Adedara, I. & Farombi, E. Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Hum. Exp. Toxicol. 37, 1054–1068 (2018).

45. Da Silva, S. et al. A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models. Inflamm. Bowel Dis. 24, 792–805 (2018).

46. Alhouayek, M., Buisseret, B., Paquot, A., Guillemot-Legris, O. & Muccioli, G. G. The endogenous bioactive lipid prostaglandin D2-glycerol ester reduces murine colitis via DP1 and PPARγ receptors. FASEB J. 32, 5000–5011 (2018).

47. Kesharwani, S. S. et al. Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation. J. Controlled Release 290, 165–179 (2018).

48. Guillemot-Legris, O. et al. Colitis Alters Oxysterol Metabolism and is Affected by 4β-Hydroxycholesterol Administration. J. Crohns Colitis 13, 218–229 (2019).

49. Singh, A. K., Hertzberger, R. Y. & Knaus, U. G. Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis. Redox Biol. 16, 11–20 (2018).

50. Koren, E. et al. ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat. Commun. 9, 4582 (2018).

51. Farombi, E. O. et al. 6-Gingerol improves testicular function in mice model of chronic ulcerative colitis. Hum. Exp. Toxicol. 37, 358–372 (2018).

52. Burrello, C. et al. Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells. Nat. Commun. 9, 5184 (2018).

53. Masquelier, J. et al. Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects. Biochim. Biophys. Acta BBA – Mol. Cell Biol. Lipids 1863, 1458–1468 (2018).

54. Acovic, A. et al. Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis. Ther. Adv. Gastroenterol. 11, 1756284818793558 (2018).

55. Ajayi, B. O., Adedara, I. A., Ajani, O. S., Oyeyemi, M. O. & Farombi, E. O. [6]-Gingerol modulates spermatotoxicity associated with ulcerative colitis and benzo[a]pyrene exposure in BALB/c mice. J. Basic Clin. Physiol. Pharmacol. 29, 247–256 (2018).

2017

56. Do, A. et al. An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice. J. Pharmacol. Exp. Ther. 360, 140–151 (2017).

57. Luna-Vital, D. A., González de Mejía, E. & Loarca-Piña, G. Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice. Plant Foods Hum. Nutr. 72, 445–447 (2017).

58. El‑Salhy, M., Umezawa, K., Hatlebakk, J. G. & Gilja, O. H. Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis. Mol. Med. Rep. 15, 2106–2112 (2017).

59. Tubbs, A. L., Liu, B., Rogers, T. D., Sartor, R. B. & Miao, E. A. Dietary Salt Exacerbates Experimental Colitis. J. Immunol. 199, 1051–1059 (2017).

60. Fehér, Á. et al. Analysing the effect of I1 imidazoline receptor ligands on DSS-induced acute colitis in mice. Inflammopharmacology 25, 107–118 (2017).

61. Gregorio, J. D. et al. Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis. PLOS ONE 12, e0171093 (2017).

62. Berlec, A. et al. Dextran sulphate sodium colitis in C57BL/6J mice is alleviated by Lactococcus lactis and worsened by the neutralization of Tumor necrosis Factor α. Int. Immunopharmacol. 43, 219–226 (2017).

63. Matsuzawa-Ishimoto, Y. et al. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J. Exp. Med. 214, 3687–3705 (2017).

64. Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M. & Santos, M. M. Dietary Heme Induces Gut Dysbiosis, Aggravates Colitis, and Potentiates the Development of Adenomas in Mice. Front. Microbiol. 8, (2017).

65. Markovic, B. S. et al. Bacterial Flora Play Important Roles in Acute Dextran Sulphate Sodium-Induced Colitis But Are Not Involved in Gal-3 Dependent Modulation of Colon Inflammation. Serbian J. Exp. Clin. Res. 18, 213–220 (2017).

66. Fugmann, T., Sofron, A., Ritz, D., Bootz, F. & Neri, D. The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis. J. Immunol. Baltim. Md 1950 198, 1357–1364 (2017).

67. Menghini, P. et al. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn’s disease-like ileitis. PloS One 12, e0174121 (2017).

68. Udden, S. M. N. et al. NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways. Cell Rep. 19, 2756–2770 (2017).

69. Khelifi, L., Soufli, I., Labsi, M. & Touil-Boukoffa, C. Immune-protective effect of echinococcosis on colitis experimental model is dependent of down regulation of TNF-α and NO production. Acta Trop. 166, 7–15 (2017).

70. Constante, M., Fragoso, G., Lupien-Meilleur, J., Calvé, A. & Santos, M. M. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm. Bowel Dis. 23, 753–766 (2017).

71. Štofilová, J. et al. Cytokine production in vitro and in rat model of colitis in response to Lactobacillus plantarum LS/07. Biomed. Pharmacother. 94, 1176–1185 (2017).

72. Pagel, R. et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 31, 4707–4719 (2017).

73. Carvajal, A. E. et al. Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes. Biochim. Biophys. Acta BBA – Mol. Basis Dis. 1863, 2126–2134 (2017).

74. Li, X. et al. Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation. J. Exp. Med. 214, 1093–1109 (2017).

75. Smole, A., Lainšček, D., Bezeljak, U., Horvat, S. & Jerala, R. A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation. Mol. Ther. 25, 102–119 (2017).

76. Zhdanov, A. V. et al. Quantitative analysis of mucosal oxygenation using ex vivo imaging of healthy and inflamed mammalian colon tissue. Cell. Mol. Life Sci. 74, 141–151 (2017).

77. Hardbower, D. M. et al. EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Oncogene 36, 3807–3819 (2017).

78. O’Sullivan, S. et al. Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes: Nitrate inhibition of MMP-9 in DSS-induced colitis. Br. J. Pharmacol. 174, 512–524 (2017).

79. Carvajal, A. E. et al. Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis. Biochim. Biophys. Acta BBA – Mol. Basis Dis. 1863, 462–473 (2017).

80. Sünderhauf, A. et al. Regulation of epithelial cell expressed C3 in the intestine – Relevance for the pathophysiology of inflammatory bowel disease? Mol. Immunol. 90, 227–238 (2017).

81. Katlinski, K. V. et al. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell 31, 194–207 (2017).

82. Adedara, I. A., Ajayi, B. O., Awogbindin, I. O. & Farombi, E. O. Interactive effects of ethanol on ulcerative colitis and its associated testicular dysfunction in pubertal BALB/c mice. Alcohol 64, 65–75 (2017).

83. Martin, A., Emmenegger, S., Hinkelmann, K. & Thönssen, B. A viewpoint-based case-based reasoning approach utilising an enterprise architecture ontology for experience management. Enterp. Inf. Syst. 11, 551–575 (2017).

2016

84. Guada, M. et al. Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease. Int. J. Pharm. 503, 196–198 (2016).

85. El-Salhy, M. & Umezawa, K. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis. Int. J. Mol. Med. 37, 556–564 (2016).

86. Kriščiukaitis, A. et al. Elaboration of Optimized Expert Knowledge Based Quantitative Features for Automatic Histological Image Evaluation. Biomed. Eng. 2016 19, (2016).

87. Dolowschiak, T. et al. IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection. Cell Host Microbe 20, 238–249 (2016).

88. Di Martino, L. et al. Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis. Cancer Res. 76, 6533–6542 (2016).

89. Bootz, F., Ziffels, B. & Neri, D. Antibody-Based Targeted Delivery of Interleukin-22 Promotes Rapid Clinical Recovery in Mice With DSS-Induced Colitis. Inflamm. Bowel Dis. 22, 2098–2105 (2016).

90. Brauer, R. et al. MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol. 9, 974–985 (2016).

91. Ahl, D. et al. Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice. Acta Physiol. 217, 300–310 (2016).

92. Chng, S. H. et al. Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity. Sci. Rep. 6, 23820 (2016).

93. Heinsbroek, S. E. M. et al. miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation. Mucosal Immunol. 9, 960–973 (2016).

94. Das, S. et al. Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. Oncogene 35, 2645–2654 (2016).

95. Ohta, T. et al. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci. Rep. 6, 23505 (2016).

96. Misiorek, J. O. et al. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 37, 777–786 (2016).

97. Yu, C. et al. Platelet-Derived CCL5 Regulates CXC Chemokine Formation and Neutrophil Recruitment in Acute Experimental Colitis. J. Cell. Physiol. 231, 370–376 (2016).

98. Di Giovangiulio, M. et al. Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor. Mol. Med. 22, 464–476 (2016).

99. Farombi, E. O. et al. Dietary protocatechuic acid ameliorates dextran sulphate sodium-induced ulcerative colitis and hepatotoxicity in rats. Food Funct. 7, 913–921 (2016).

100. Simovic Markovic, B. et al. Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis. Stem Cells International (2016). doi:10.1155/2016/2640746

101. Matthis, A. L. et al. Importance of the Evaluation of N-Acetyltransferase Enzyme Activity Prior to 5-Aminosalicylic Acid Medication for Ulcerative Colitis. Inflamm. Bowel Dis. 22, 1793–1802 (2016).

102. El-Salhy, M. & Umezawa, K. Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats. Int. J. Mol. Med. 37, 1457–1464 (2016).

103. Goodman, W. A. et al. KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation. Mucosal Immunol. 9, 1250–1262 (2016).

104. Vázquez-Carretero, M. D. et al. The Synaptojanins in the murine small and large intestine. J. Bioenerg. Biomembr. 48, 569–579 (2016).

105. Martin, J. C. et al. IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis. Mucosal Immunol. 9, 539–549 (2016).

106. Márquez-Flores, Y. K., Villegas, I., Cárdeno, A., Rosillo, M. Á. & Alarcón-de-la-Lastra, C. Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. J. Nutr. Biochem. 30, 143–152 (2016).

107. De Fazio, L. et al. Dietary Geraniol by Oral or Enema Administration Strongly Reduces Dysbiosis and Systemic Inflammation in Dextran Sulfate Sodium-Treated Mice. Front. Pharmacol. 7, (2016).

108. Beloqui, A. et al. A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease. Colloids Surf. B Biointerfaces 143, 327–335 (2016).

109. Gerling, M. et al. Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat. Commun. 7, 12321 (2016).

110. Jia, L.-G. et al. A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection. J. Immunol. Baltim. Md 1950 197, 377–386 (2016).

111. Lee, S. et al. Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Sci. Rep. 6, 26923 (2016).

112. Aden, K. et al. Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation. Cell Rep. 16, 2208–2218 (2016).

113. Bosma, M. et al. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nat. Commun. 7, 11314 (2016).

114. Elmasry, A., Daba, M.-H. & El-Karef, A. Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice. Br. J. Med. Med. Res. 16, 1–19 (2016).

115. Helenius, T. O., Antman, C. A., Asghar, M. N., Nyström, J. H. & Toivola, D. M. Keratins Are Altered in Intestinal Disease-Related Stress Responses. Cells 5, 35 (2016).

116. O’Shea, C. J. et al. The effect of algal polysaccharides laminarin and fucoidan on colonic pathology, cytokine gene expression and Enterobacteriaceae in a dextran sodium sulfate-challenged porcine model. J. Nutr. Sci. 5, (2016).

117. Däbritz, J., Judd, L. M., Chalinor, H. V., Menheniott, T. R. & Giraud, A. S. Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells. Sci. Rep. 6, 20584 (2016).

118. Simovic Markovic, B. et al. Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages. J. Crohns Colitis 10, 593–606 (2016).

119. Shen, F. et al. Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis. J. Agric. Food Chem. 64, 1111–1121 (2016).

2015
120. Heinsbroek, S. E. M. et al. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation. Nutr. Res. 35, 1106–1112 (2015).

121. Sommer, F. & Bäckhed, F. The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. Mucosal Immunol. 8, 372–379 (2015).

122. Moon, C. et al. Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation. Nature 521, 90–93 (2015).

123. Fornasa, G. et al. Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin. J. Allergy Clin. Immunol. 136, 413–422 (2015).

124. Elkatary, R. et al. Effect of Different Doses of Sitagliptin in Treatment of Experimentally Induced Colitis in Mice. Br. J. Pharm. Res. 7, 140–151 (2015).

125. Ajayi, B. O., Adedara, I. A. & Farombi, E. O. Pharmacological activity of 6-gingerol in dextran sulphate sodium-induced ulcerative colitis in BALB/c mice. Phytother. Res. PTR 29, 566–572 (2015).

126. Elkatary, R., Abdelrahman, K., Hassanin, A. & Elmasry, A. A Comparative Study between the Effect of Simvastatin and Sitagliptin Combined and the Effect of a Large Dose of Each in an Early Treatment of Experimentally Induced Colitis in Mice. 17

127. Asghar, M. N. et al. The Amount of Keratins Matters for Stress Protection of the Colonic Epithelium. PLOS ONE 10, e0127436 (2015).

128. Petrolis, R. et al. Digital imaging of colon tissue: method for evaluation of inflammation severity by spatial frequency features of the histological images. Diagn. Pathol. 10, 159 (2015).

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SELECTED OLDER PUBLICATIONS
143. Sommer, F. et al. Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture. PLOS ONE 9, e85254 (2014).

144. Wagner, A. E. et al. DSS-induced acute colitis in C57BL/6 mice is mitigated by sulforaphane pre-treatment. J. Nutr. Biochem. 24, 2085–2091 (2013).

145. Beloqui, A. et al. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. Int. J. Pharm. 454, 775–783 (2013).

146. Thaker, A. I., Shaker, A., Rao, M. S. & Ciorba, M. A. Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS). JoVE J. Vis. Exp. e4100 (2012). doi:10.3791/410

147. Van Crombruggen, K. et al. Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis. Eur. J. Pharmacol. 579, 337–349 (2008).

148. Ten Hove, T., Drillenburg, P., Wijnholds, J., te Velde, A. A. & van Deventer, S. J. H. Differential Susceptibility of Multidrug Resistance Protein-1 Deficient Mice to DSS and TNBS-Induced Colitis. Dig. Dis. Sci. 47, 2056–2063 (2002).

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