DEPArray™ NxT 單細胞分離篩選系統

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DEParray™ 在腫瘤學Oncology的應用

Cariati et al, Int Journal of Molecular Sciences 2019, “Dissecting Intra-Tumor Heterogeneity by the Analysis of Copy Number Variations in Single Cells: The Neuroblastoma Case Study”

Meyer et al, Human Pathology 2019 “Co-expression of cytokeratin and vimentin in colorectal Cancer highlights a subset of tumor buds and an atypical Cancer-associated stroma”

Hodara et al, Journal od Clinical Oncology Insights 2019, “Multi-parametric liquid biopsy analysis in metastatic prostate cancer”

Dorssers et al, British Journal of Cancer 2019, “Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development”

Rihawi et al, Translational Oncology 2019, “Amplification as a Potential Mechanism of Primary Resistance to Crizotinib in ALK-Rearranged Non-Small Cell Lung Cancer: A Brief Report”

Vishnoi et al, Cancer Research 2018, “Targeting USP7 Identifies a MetastasisCompetent State within Bone Marrow–Resident Melanoma CTCs”

De Laere et al, Clinical Cancer Research 2018, “TP53 outperforms other androgen receptor biomarkers to predict abiraterone or enzalutamide outcome in metastatic castration-resistant prostate cancer”

Chalopin et al, Journal of Bone Oncology, 2018 “Isolation of circulating tumor cells in a preclinical model of osteosarcoma: effect of chemotherapy”

Petrossian et al, Oncotarget 2018, “ERα-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer”

Ji Won Lee et al, Journal of Applied Genetics 2018, “Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing”

Ferrarini A et al, PLOS ONE 2018, “A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products”

Boulding et al, Scientific Reports 2018, “LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer”

Paoletti et al, Cancer Research 2017, “Comprehensive mutation and copy number profiling in archived circulating breast cancer tumor cells documents heterogeneous resistance mechanisms”

Boral et al, Nature Communications 2017, “Molecular characterization of breast cancer CTCs associated with brain metastasis”

Mesquita et al, Molecular Oncology 2017, “Molecular analysis of single circulating tumour cells following long-term storage of clinical samples”

Paolillo et al, Clinical Cancer Research 2017, “Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells”

Palmirotta et al, Cancer Genomics and Proteomics 2017, “Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)”

Rapp C et al, Acta Neuropathol 2017, “Identification of T cell target antigens in glioblastoma stem‑like cells using an integrated proteomics‑based approach in patient specimens”

Bingham C et al, Breast Cancer Res Treat 2017, “Mutational studies on single circulating tumor clles isolated form the blood of inflammatory breast cancer patients”

Tellez Gabriel M et al, European Journal of Cell Biology 2017, “Analysis of gap junctional intercellular communications using a dielectrophoresis-based microchip”

De Laere B et al, JTS 2016, “Patients with metastatic hormone receptor-positive breast cancer express PIK3CA oncogene mutational heterogeneity in circulating tumor cells”

Carter L et al, Nature Medicine 2016, “Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemo sensitive and chemo refractory small-cell lung cancer”

Zhaomei Mu et al, IJMC 2016, “Detection and Characterization of Circulating Tumor Associated Cells in Metastatic Breast Cancer”

Shaw J et al, Clinical Cancer Research 2016, “Mutation analysis of cell-free DNA and single circulating tumor cells in metastatic breast cancer patients with high CTC counts”

Millner LM et al, Cancer Research Frontiers 2016, “Comprehensive isolation, identification, and nucleic acid analysis of single breast cancer cells: CTC-isoTECH”

De Luca F et al, Oncotarget 2016, “Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer”

Bulfoni M et al, Breast Cancer Research 2016, “In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis”

Yee S.S et al, Molecular Genetics and Genomic Medicine 2016, “A novel approach for next-generation sequencing of circulating tumor cells”

Bolognesi C et al, Nature Scientific Reports 2016, “Digital Sorting of Pure Cell Populations Enables Unambiguous Genetic Analysis of Heterogeneous Formalin-Fixed Paraffin-Embedded Tumors by Next Generation Sequencing”

Rothwell G et al, Molecular Oncology 2015, “Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample”

Vishnoi M et al, Nature Scientific Reports 2015, “The isolation and characterization of CTC subsets related to breast cancer dormancy”

Salvianti et al, Biomolecular Detection and Quantification 2015, “Feasibility of a workflow for the molecular characterization of singlecells by next generation sequencing”

Ewelina Krzywinska et al, EBioMedicine 2015, “Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients with Hematological Cancers”

Maltoni R et al, Cancer Letters 2015, “Circulating tumor cells in early breast cancer: A connection with vascular invasion”

Pestrin M et al, Molecular Oncology 2014, “Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients”

Fernandez S.V. et al, Breast Cancer Research 2014, “TP53 mutations detected in circulating tumor cellspresent in the blood of metastatic triple negative breast cancer patients”

Carpenter E, et al, Frontiers in Oncology 2014, “Dielectrophoretic capture and genetic analisys of single neuroblastoma tumor cells”

Hodgkinson C.L.et al, Nature Medicine 2014, “Tumorigenicity and genetic profiling of Circulating Tumor Cells in Small Cell Lung Cancer”

Peeters DJE, et al. British Journal of Cancer 2013, “Semiautomated isolation and molecular characterization of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting”

Fabbri F, et al. Cancer Letters 2013, “Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs”

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DEParray™ 在法醫鑑識Forensic的應用

Anslinger et al, Rechtsmedizin 2019, “Deconvolution of blood-blood mixtures using DEPArrayTM separated single cell STR profiling”

Anslinger K et al, International Journal of Legal Medicine 2018, “Whose blood is it? Application of DEPArray™ technology for the identification of individual/s who contributed blood to a mixed stain”

Williamson VR et al, FSI Genetics 2018, “Enhanced DNA Mixture Deconvolution of Sexual Offense Samples Using the DEPArray^TM System”

Aslinger K et al, Rechtsmedizin 2017, “Application of DEPArray™ technology for the isolation of white blood cells from cell mixtures in chimerism analysis”

Fontana F et al, FSI Genetics 2017, “Isolation and genetic analysis of pure cells from forensic biological mixtures: The precision of a digital approach”

Hansson O et al, FSI Genetics 2017, “Characterization of artefacts and drop-in events using STR-validator and single-cell analysis”

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DEParray™ 在蠟塊包埋FFPE的應用

Meyer et al, Human Pathology 2019 “Co-expression of cytokeratin and vimentin in colorectal Cancer highlights a subset of tumor buds and an atypical Cancer-associated stroma”

Dorssers et al, British Journal of Cancer 2019, “Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development”

Isidori et al, BMC Cancer 2018, “Genomic profiles of primary and metastatic esophageal adenocarcinoma identified via digital sorting of pure cell populations: results from a case report”

Ji Won Lee et al, Journal of Applied Genetics 2018, “Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing”

Bolognesi C et al, Nature Scientific Reports 2016, “Digital Sorting of Pure Cell Populations Enables Unambiguous Genetic Analysis of Heterogeneous Formalin-Fixed Paraffin-Embedded Tumors by Next Generation Sequencing”

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DEParray™ 在分離幹細胞Isolation of Stem Cells的應用

Silvestris et al, Human Reproduction 2018, “In vitro differentiation of human oocytelike cells from oogonial stem cells: single-cell isolation and molecular characterization”

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DEParray™ 在蠟塊包埋FFPE應用的社論

Kathy Liszewski, GEN 2016, “The Next Next Thing in Sequencing”

Farideh Bischoff, Nicolò Manaresi and Chiara Bolognesi, GEN 2015, “Isolation of Pure Tumor Cell Populations”

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DEParray™技術出版品

以下參考文獻是有關於介電泳技術和移動細胞的原理

Abonnenc M et al, J Immunol 2013, “Lysis-on-Chip of Single Target Cells following Forced Interaction with CTLs or NK Cells on a Dielectrophoresis-Based Array”

Abonnenc M et al, Anal. Chem. 2013, “Programmable Interactions of Functionalized Single Bioparticles in a Dielectrophoresis-Based Microarray Chip”

Gagnon ZR, Electrophoresis 2011, “Cellular dielectrophoresis: applications to the characterization, manipulation, separation and patterning of cells”

Fabbri E et al, J Appl Polymer Sci 2008, “Levitation and movement of tripalmitin-based cationic lipospheres on a dielectrophoresis-based lab-on-a-chip device”

Borgatti M et al, Int J Mol Med 2008, “New trends in non-invasive prenatal diagnosis: Applications of dielectrophoresis-based Lab-on-a-chip platforms to the identification and manipulation of rare cells”

Vulto P et al, J Micromech Microeng 2006, “Selective sample recovery of DEP-separated cells and particles by phaseguide-controlled laminar flow”

Fuchs AB et al, Lab Chip 2005, “Electronic Sorting and Recovery of Single Live Cells From Microlitre Sized Samples”

Borgatti M et al, Int J Mol Med 2005, “Separation of White Blood Cells From Erythrocytes on a Dielectrophoresis (DEP) Based ‘Lab-On-A-Chip’ Device”

Borgatti M et al, International Journal Oncology 2005, “Dielectrophoresis-based ‘Lab-on-a-chip’ devices for programmable binding of microspheres to target cells”

Abonnenc M et al, NanoBiotechnology 2005, “A dielectrophoretic microchip for controlled cell targeting with functionalized microspheres”

Medoro G et al, IEEE Sensors J 2003, “A lab-on-a-chip for cell detection and manipulation”

Altomare L et al, Biotechnol and Bioeng 2003, “Levitation and movement of human tumor cells using a printed circuit board device based on software-controlled dielectrophoresis”

Gascoyne PR et al, Electrophoresis 2002, “Particle separation by dielectrophoresis”

Archer S et al, Biochem Biophys Res Commun 1999, “Cell Reactions to Dielectrophoretic Manipulation“

Brochure

• DeparrayNxT_%20Brochure.pdf