Biocrates AbsoluteIDQ® p180 Kit

AbsoluteIDQ® p180 Kit代謝體研究捷徑,採用質譜儀定量,結果可重複性有助於進階研究。只需10ul樣品即可分析,再現性高。含有188種內源性代謝產物,包括5種分類( acylcarnitines, amino acids, hexoses, phospho- and sphingolipids and biogenic amines)。

Biocrates life sciences ag

AbsoluteIDQ® p180 Kit 可以同時定量188種代謝體,反應了多種病理生理過程,例如引起粒線體功能障礙或異常的細胞週期控制。目前已經有超過800多篇科學論文發表中使用此技術,使其成為代謝體生物標示研究的公認標準。由於所需樣品量小,只需10ul ,高通量分析,重複性高,適合用於生物醫學研究的各個階段,從細胞培養到齧齒類動物模式,進而大規模流行病學的研究皆適用。

  • 少量樣品需求,只需10 ul
  • 從動物模組到臨床測試的實驗數據 皆可相互對照
  • 簡單清楚的自動化工作流程
  • 全球廣泛使用

p180 優勢

Ready

立即使用

  • 一天之內完成實驗
  • 完整配套,無需測試方法和試劑
  • 多種儀器皆可建立標準流程
Volume

高速分析&少量樣品需求

  • 一台儀器每星期可分析多達400個樣品
  • 多數體液只需10ul進行分析
Value

可驗證的實驗數據

  • 可使用人類血漿進行驗證
  • 多種物種皆已建立實驗流程
  • 支援臨床前與臨床研究
Quality

高品質實驗數據

  • 代謝物定量
  • 分析結果準確度高
  • 不同實驗室與儀器間有實驗再現性
Workflow

簡單、指引清楚的自動化工作流程

  • 工作流程指引
  • 自動偵測訊號,量化,技術驗證
Network

技術使用廣泛

  • 全球100多個實驗室使用
  • 成功地被應用於學術研究
    與前10大製藥廠的其中8間

可偵測的代謝物分類

簡單、指引清楚的自動化工作流程

Workflow

代謝體與相關研究

Metabolic Pathways

適用的樣品種類

  • Human plasma* or serum 人類的血漿、血清
  • animal plasma or serum 動物的血漿、血清
  • tissue extracts of different species
  • cell lysate 細胞裂解
  • cell culture supernatant 細胞培養上層液
  • CSF 腦脊髓液
  • urine (with restrictions) 尿液
  • feces (human tested) 糞便
  • BALF 支氣管肺泡沖洗液
  • further fluid biological matrices (please ask customer support)
  • Citrate plasma is not accepted 不接受檸檬酸鹽血漿

適用領域

可研究樣品

biofluids (plasma, serum, urine, CSF, milk,…), tissue, cell culture samples, dried blood spots, …

可研究物種

human, non-human primates, mouse, rat, cow, pig, chicken, horse, zebrafish,…

MetabolitesMetabolite Class(es)Disease
  • Alanine
  • Glycine
  • Leucine
  • Valine
  • Carnosine
  • L-DOPA
  • Amino acids
  • Biogenic amines
  • Phosphatidylcholines
Neurodegenerative diseases

e.g.

  • Alzheimer’s disease 阿茲海默症
  • Parkinson’s disease 帕金森氏症
  • Huntington’s disease 亨丁頓舞蹈症
  • Alanine
  • Glutamine
  • Glutamic acid
  • Glycine
  • Creatine
  • Proline taurine
  • Valine
  • Asparagine
  • Lysine
  • and many others
  • Amino acids
  • Biogenic amines
  • Lysophosphatidylcholines
Cancer 癌症
  • Isoleucine
  • Leucine
  • Phenylalanine
  • Tyrosine
  • Valine
  • Creatinine
  • PC aa C34:4
  • SM C14:0
  • Glucose
  • Amino acids
  • Biogenic amines
  • Phosphatidylcholines
  • Sphingo-myelins
  • Hexoses
Diabetes 糖尿病
  • Alanine
  • Aspartate
  • Citrate
  • Creatinine
  • Fructose
  • Glucose
  • Glutamine
  • Glycine
  • Histidine
  • Isoleucine
  • Proline
  • Serine
  • Threonine
  • Tryptophan
  • Valine
  • Amino acids
  • Hexoses
Cardiovascular disease 心血管疾病

應用領域

AbsoluteIDQ® p180 Kit 在許多應用方面都有論文持續發表,心血管疾病、糖尿病、肝腎疾病、神經內科、腫瘤學、老化、流行病學、腸胃病、微生物學、製藥等等。
詳細的文獻查詢請進入以下連結,從2009~2017年的論文,可以分類查詢。
https://www.biocrates.com/publications/publications

適用的質譜儀機型

試劑盒內容物

(一盤96well 最多可以檢測82個樣品)

ProductDescriptionDetails
AbsoluteIDQ® Kit PlateA 96 deepwell plate plus a filter plate attached with sealing tapeSealed under nitrogen in a plastic bag
Silicone mat cover for plateCovers the plate after sample preparation, 2 items
Biocrates® Solvent ISealed glass ampoule, 2 itemsUsed as FIA running solvent
Biocrates® Quality Controls3 vials
Biocrates® Standards7 vialsUsed as calibration standards for the LC- MS/MS assay
Biocrates® Internal Standards1 vial
96 deepwell capture plateFor diluting sample extracts obtained after Kit preparation
USB memory stick
  • MetIDQ™ Software
  • OracleXE (Express Edition) database
  • Acquisition and quantification methods
  • User Manual and Analytical Specifications
  • StatPack User Manual
  • RatioExplorer User Manual

AbsoluteIDQ® p180 Kit

產品貨號產品名稱產品數量
聯絡我們AbsoluteIDQ® p180 Kit-
聯絡我們AbsoluteIDQ® p180 Starter Kit-
9120052120189MetIDQ™ StatPack Module-
聯絡我們Metabolic Phenotyping Services-
聯絡我們Data Analysis Service-

心臟代謝疾病 Cardiometabolic Diseases

心臟病 Cardiology

糖尿病 Diabetes

  • Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum Humer et al., 2016
  • Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status. Allam-Ndoul et al., 2016
  • Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype Kim et al., 2016
  • Associations between branched chain amino acid levels, obesity and cardiometabolic complications Allam-Ndoul et al., 2015
  • Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice Franko et al., 2016
  • Deletion of mouse Alkbh7 leads to obesity Solberg et al., 2013 J Mol Cell Biol 2013, 5 (3), 194–203.
  • Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites Klöting et al., 2015
  • Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance Ferrannini et al., 2013 Diabetes 2013, 62 (5), 1730–1737.
  • Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes Xu et al., 2015
  • Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs Metzler-Zebeli et al., 2015
  • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis Lotta et al., 2016 PLOS Medicine
  • High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice. Kahle et al., 2015
  • Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach Floegel et al., 2013 Diabetes 2013, 62 (2), 639–648.
  • Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol is Associated with Alterations in the Gut Microbiome Sung et al., 2016 Diabetes
  • Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up Mook et al., 2014
  • Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
  • Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother–child cohort in Crete, Greece Perng et al., 2016 Obesity Science & Practice
  • Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels Binder et al., 2013 PLoS ONE 2013, 8 (9), e74705.
  • Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
  • Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals Böhm et al., 2014
  • Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism Stechemesser et al., 2016 Molecular Metabolism
  • Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism. Stechemesser et al., 2017 Molecular Metabolism
  • Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals Gao et al., 2016
  • Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women Merz et al., 2016
  • The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Blutke et al., 2017 Molecular Metabolism
  • Tryptophan as a Surrogate Prognostic Marker for Diabetic Nephropathy. Chou et al., 2017 J Diabetes Investig.
  • Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes Isherwood et al., 2017 FASEB Journal

肝病 Hepatology

  • Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver Feldman et al., 2016
  • Diagnosing Fatty Liver Disease: A Comparative Evaluation of Metabolic Markers, Phenotypes, Genotypes and Established Biomarkers Siegert et al., 2013 PLoS ONE 2013, 8 (10), e76813.
  • Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach Yu et al., 2016
  • Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Anzai et al., 2017 Scientific Reports
  • Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation Cheema et al., 2014
  • Loss of the RNA polymerase III repressor MAF1 confers obesity resistance Bonhoure et al., 2015
  • Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels Dahlhoff et al., 2014
  • Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
  • Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children Bhattacharyya et al., 2014
  • The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Kosack et al., 2017 Scientific Reports

腎臟病 Nephrology

  • Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease Nkuipou-Kenfack et al., 2014
  • Metabolites associate with kidney function decline and incident chronic kidney disease in the general population Goek et al., 2013
  • Nephrol. Dial. Transplant. 2013, 28 (8), 2131–2138.
  • Metabolomic Profiling in Individuals with a Failing Kidney Allograft Bassi et al., 2017 PLOS One
  • Plasma and urinary amino acid metabolomic profiling in patients with different levels of kidney function Duranton et al., 2014
  • Tryptophan as a Surrogate Prognostic Marker for Diabetic Nephropathy. Chou et al., 2017 J Diabetes Investig.

神經內科 Neurology

  • Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia. Marini et al., 2017 Front Physiol.
  • Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome Pan et al., 2015
  • Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins Voyle et al., 2016
  • Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals Casanova et al., 2016
  • Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism Patin et al., 2016
  • Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms Sirrs et al., 2015
  • Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Tang et al., 2017 Scientific Reports
  • Effect of sleep deprivation on the human metabolome. Davies et al., 2014
  • Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach Yu et al., 2016
  • Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy Cermenati et al., 2015
  • Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease. Pan et al., 2017 Metabolites
  • Metabolic profiling of presymptomatic Huntington’s disease sheep reveals novel biomarkers Skene et al., 2017 Scientific Reports
  • Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease Fiandaca et al., 2015
  • Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS) Li et al., 2016
  • Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Kriisa et al., 2017 J Proteome Res.
  • Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study Li et al., 2017 Alzheimer's & Dementia
  • Sphingomyelin SM(d18:1/18:0) is Significantly Enhanced in Cerebrospinal Fluid Samples Dichotomized by Pathological Amyloid-β42, Tau, and Phospho-Tau-181 Levels Koal et al., 2014
  • Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. St John-Williams et al., 2017 Scientific Data
  • Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis Koido et al., 2016
  • The Brain Metabolome of Male Rats across the Lifespan Zheng et al., 2016
  • The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment Klavins K., Koal T., Dallmann G. et al., 2015
  • Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+) Krug et al., 2014

營養和生活方式 Nutrition and Lifestyle

  • 12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study Auer et al., 2016 Scientific Reports
  • A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. Goffredo et al., 2017 Nutrients
  • Application of metabolomics to measure the Alberta “Foodome” Borzouie, Shima Thesis
  • Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype Kim et al., 2016
  • Associations between branched chain amino acid levels, obesity and cardiometabolic complications Allam-Ndoul et al., 2015
  • Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. Keshteli et al., 2017 World J Gastroenterol.
  • Effect of sleep deprivation on the human metabolome. Davies et al., 2014
  • Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Xu et al., 2013 BMC Med 2013, 11, 60.
  • Environmental Enteric Dysfunction is Associated with Carnitine Deficiency and Altered Fatty Acid Oxidation Semba et al., 2017 Ebiomedicine
  • Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs Metzler-Zebeli et al., 2015
  • Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view Turroni et al., 2016
  • High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Datta et al., 2017 Scientific Reports
  • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) Peterson et al., 2016
  • Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach Floegel et al., 2013 Diabetes 2013, 62 (2), 639–648.
  • Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome. Sung et al., 2016 Diabetes
  • Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
  • Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels Binder et al., 2013 PLoS ONE 2013, 8 (9), e74705.
  • Loss of the RNA polymerase III repressor MAF1 confers obesity resistance Bonhoure et al., 2015
  • Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
  • Metabolic alterations in children with environmental enteric dysfunction Semba et al., 2016
  • Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort Schmidt et al., 2015
  • Metabolomics evidences plasma and serum biomarkers differentiating two heavy pig breeds Bovo et al., 2016
  • Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake Mathew et al., 2014
  • Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women Moazzami et al., 2014
  • Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows Huber et al., 2016
  • Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome
  • Plasma amino acids and metabolic profiling of dairy cows in response to a bolus duodenal infusion of leucine Sadri et al., 2017 PLOS One
  • Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort Schmidt et al., 2015
  • Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals Gao et al., 2016
  • Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women Merz et al., 2016
  • The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life. Winkels et al., 2014
  • The Human Early-Life Exposome (HELIX): Project Rationale and Design Vrijheid et al., 2014
  • The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women Bub et al., 2016
  • Transglycosylated Starch Improves Insulin Response and Alters Lipid and Amino Acid Metabolome in a Growing Pig Model Newman et al., 2017 Nutrients
  • Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes Isherwood et al., 2017 FASEB Journal

腫瘤科學 Oncology

  • Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer Aust et al., 2017 Scientific Reports
  • Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study Stepien et al., 2016
  • BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism Wang et al., 2015
  • Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo Brunelli et al., 2016
  • Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS. Caiola et al., 2016
  • Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder Piyarathna et al., 2017 European Urology Focus
  • Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death. Klutzny et al., 2017 Cell Death Dis.
  • Mass Spectrometry-Based Quantitative Metabolomics Revealed a Distinct Lipid Profile in Breast Cancer Patients Qiu et al., 2013 Int J Mol Sci 2013, 14 (4), 8047–8061.
  • Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia Giskeødegård et al., 2015
  • Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation Laiakis et al., 2014
  • Metabolomic profile in pancreatic cancer patients: a consensusbased approach to identify highly discriminating metabolites Di Gangi et al., 2015
  • Metabolomics for Biomarker Discovery in Gastroenterological Cancer Nishiumi et al., 2014
  • Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma. Ang et al., 2017 Mol Cancer Ther.
  • Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma Muqaku et al., 2016
  • Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. Mugaku et al., 2017 Mol Cell Proteomics
  • Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer Miolo et al., 2016
  • Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. Ang et al., 2016
  • Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition. Schmidt et al., 2017 BMC Medicine
  • Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
  • The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life. Winkels et al., 2014

藥物研究 Pharmaceutical Research

  • Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice Franko et al., 2016
  • Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock. Cambiaghi et al., 2017 Scientific Reports
  • Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis. Bothe et al., 2017 J Toxicol Sci.
  • Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism Patin et al., 2016
  • Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo Brunelli et al., 2016
  • Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites Klöting et al., 2015
  • Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS. Caiola et al., 2016
  • Differential cellular metabolite alterations in HaCaT cells caused by exposure to the aryl hydrocarbon receptor-binding polycyclic aromatic hydrocarbons chrysene, benzo[a]pyrene and dibenzo[a,l]pyrene Potratz et al., 2016
  • Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes Xu et al., 2015
  • Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a Highthroughput Targeted Metabolomics Approach Yu et al., 2017 Scientific Reports
  • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) Peterson et al., 2016
  • Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation Cheema et al., 2014
  • Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation Laiakis et al., 2014
  • Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome
  • Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma. Ang et al., 2017 Mol Cancer Ther.
  • Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats de Souza et al., 2017 Toxicology
  • Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer Miolo et al., 2016
  • Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. Ang et al., 2016
  • Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Kriisa et al., 2017 J Proteome Res.
  • Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone Meier et al., 2015
  • Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus Pena et al., 2016
  • Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children Bhattacharyya et al., 2014
  • Targeted Metabolomic Profiling Indicates Structure-based Perturbations in Serum Phospholipids in Children with Acetaminophen Overdose Bhattacharyya et al., 2016
  • Targeted metabolomics of nonhuman primate serum after exposure to ionizing radiation: potential tools for high-throughput biodosimetry Pannkuk et al., 2016
  • Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis Koido et al., 2016
  • Utilization of Metabolomics to Identify Biomarkers in Hematological Malignancies: Role of IDO and the Tryptophan Pathway Finger et al., 2017 Blood
 

其他研究領域 Other Research Fields

老化 Aging

  • Aging-related changes in mouse serum glycerophospholipid profiles Kim et al., 2014
  • Effect of sleep deprivation on the human metabolome. Davies et al., 2014
  • Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium Kiermayer et al., 2015
  • Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis Zhang et al., 2016
  • Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients Zhang et al., 2015
  • Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging Moaddel et al., 2016
  • Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. Mayer et al., 2017 Mol Cell Proteomics

生物程序 Bioprocessing

  • Reduced quenching and extraction time for mammalian cells using filtration and syringe extraction Hernández et al., 2014

流行病學與遺傳學 Epidemiology & Genetics

  • Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals. Pietzner et al., 2017 BMC Medicine
  • Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study Xu et al., 2013 BMC Med 2013, 11, 60.
  • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis Lotta et al., 2016 PLOS Medicine
  • Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort Schmidt et al., 2015
  • Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study. Rist et al., 2017 PLOS One
  • Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort Schmidt et al., 2015
  • Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition. Schmidt et al., 2017 BMC Medicine
  • Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study Li et al., 2017 Alzheimer's & Dementia
  • Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis Dietrich et al., 2016
  • Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC Carayol et al., 2015
  • Short-term NO 2 exposure is associated with long-chain fatty acids in prospective cohorts from Augsburg, Germany: results from an analysis of 138 metabolites and three exposures Ward-Caviness et al., 2016

消化內科 Gastroenterology

  • Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. Keshteli et al., 2017 World J Gastroenterol.
  • Metabolic alterations in children with environmental enteric dysfunction Semba et al., 2016
  • Metabolomics for Biomarker Discovery in Gastroenterological Cancer Nishiumi et al., 2014
  • Metabonomics Reveals Metabolite Changes in Biliary Atresia Infants. Zhou et al., 2015

婦科與生育 Gynecology & Fertility

  • A metabolomics approach to characterize phenotypes of metabolic transition from late pregnancy to early lactation in dairy cows Kenéz et al., 2016
  • A Predictive Metabolic Signature for the Transition from Gestational Diabetes to Type 2 Diabetes Allalou et al., 2016
  • Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum Humer et al., 2016
  • Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Anzai et al., 2017 Scientific Reports
  • Integrated Proteomic and Metabolomic prediction of Term Preeclampsia. Bahado-Singh et al., 2017 Scientific Reports
  • Lactation is associated with altered metabolomic signatures in women with gestational diabetes Much et al., 2016
  • Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children Englich et al., 2017 International Journal of Obesity
  • Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study Gelaye et al., 2016
  • Metabolomic prediction of fetal congenital heart defect in the first trimester Bahado-Singh et al., 2014
  • Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women Moazzami et al., 2014
  • Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows Huber et al., 2016
  • Non-invasive prediction of embryo developmental potential by embryo culture medium quantitative secretomic Camillo et al., 2015
  • Perinatal Asphyxia: A Review from a Metabolomics Perspective Fattuoni et al., 2015
  • Targeted metabolomics reveals reduced levels of polyunsaturated choline plasmalogens and a smaller dimethylarginine/arginine ratio in the follicular fluid of patients with a diminished ovarian reserve. de la Barca et al., 2017 Hum. Reprod.

炎症和免疫學 Inflammation & Immunology

  • Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer Aust et al., 2017 Scientific Reports
  • Admission levels of asymmetric and symmetric dimethylarginine predict longterm outcome in patients with communityacquired pneumonia Voegeli et al., 2017
  • Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation. Ottas et al., 2017 PLOS One
  • Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock. Cambiaghi et al., 2017 Scientific Reports
  • Classification of osteoarthritis phenotypes by metabolomics analysis Zhang et al., 2014
  • Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation Tahir et al., 2017 Analytical Chemistry
  • Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals. Pietzner et al., 2017 BMC Medicine
  • Comprehensive proteomic and metabolomic signatures of nontypeable Haemophilus influenzae-induced acute otitis media reveal bacterial aerobic respiration in an immunosuppressed environment Harrison et al., 2015
  • High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Datta et al., 2017 Scientific Reports
  • Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. Zhang et al, 2017 PLOS One
  • Metabolomic Profiling in Individuals with a Failing Kidney Allograft Bassi et al., 2017 PLOS One
  • Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach Ferrario et al., 2016
  • Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma Muqaku et al., 2016
  • Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients Wu et al., Scientific Reports 2017 Scientific Reports
  • The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Kosack et al., 2017 Scientific Reports
  • The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease. Ottas et al., 2017 Archives of dermatological research
  • Utilization of Metabolomics to Identify Biomarkers in Hematological Malignancies: Role of IDO and the Tryptophan Pathway Finger et al., 2017 Blood

微生物 Microbiome

  • Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view Turroni et al., 2016
  • Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol is Associated with Alterations in the Gut Microbiome Sung et al., 2016 Diabetes
  • Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome. Sung et al., 2016 Diabetes
  • Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice Ryan et al., 2017 Microbiome

肺病 Pulmonology

  • Admission levels of asymmetric and symmetric dimethylarginine predict longterm outcome in patients with communityacquired pneumonia Voegeli et al., 2017
  • Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases Herberth et al., 2015
  • Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. Naz et al., 2017 The European Respiratory Journal

技術 Technology

  • Differential cellular metabolite alterations in HaCaT cells caused by exposure to the aryl hydrocarbon receptor-binding polycyclic aromatic hydrocarbons chrysene, benzo[a]pyrene and dibenzo[a,l]pyrene Potratz et al., 2016
  • Optimizing Urine Processing Protocols for Protein and Metabolite Detection Siddiqui et al., 2015
  • Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis Dietrich et al., 2016
  • Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method Muschet et al., 2016
  • Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. St John-Williams et al., 2017 Scientific Data
  • Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples Breier et al., 2014
  • The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age Trabado et al., 2017 PLOS One
  • The human saliva metabolome Dame et al., 2015