microRNA

Biomarker Discovery

A specific miRNA signature in the peripheral blood of glioblastoma patients.

Roth P, Wischhusen J, Happold C, Anoop Chandran P et al. (2011)

J Neurochem. 2011 Aug;118(3):449-57. doi: 10.1111/j.1471-4159.2011.07307.x. Epub 2011 Jun 17

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Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis

Keller A, Leidinger P, Gislefoss R, Haugen A, Langseth H et al. (2011)

RNA Biol., Volume 8, Issue 3 May/June 2011

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Specific peripheral miRNA profiles for distinguishing lung cancer from COPD

Leidinger P, Keller A, Borries A, Huwer H, Rohling M et al. (2011)

Lung Cancer, 2011 Mar 7

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The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism

Shah A, Leidinger P, Keller A, Wendschlag A, Backes C et al. (2011)

RNA Biol., Volume 8, Issue 1, Pages 77–81, January/February 2011

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MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction

Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F et al. (2010)

Basic Research in Cardiology DOI: 10.1007/s00395-010-0123-2

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Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening

Häusler S, Keller A, Chandran A, Ziegler K, Zipp K, Heuer S et al. (2010)

British Journal of Cancer 103(5):693

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High-throughput miRNA profiling of human melanoma blood samples

Leidinger P, Keller A, Borries A, Reichrath J, Rass K et al. (2010)

BMC Cancer, 19:262

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A dictionary on microRNAs and their putative target pathways

Backes C, Meese E, Lenhof HP and Keller A (2010)

Nucleic Acids Research 38(13): 4476-86

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miRNAs in lung cancer – Studying complex fingerprints in patient’s blood cells by microarray experiments

Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F et al. (2009)

BMC Cancer 9:353

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Multiple Sclerosis – MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls

Keller A, Leidinger P, Lange J, Borries A, Schroers H et al. (2009)

PLoS ONE4(10):e7440

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miRNA profiling

A specific miRNA signature in the peripheral blood of glioblastoma patients.

Roth P, Wischhusen J, Happold C, Anoop Chandran P et al. (2011)

J Neurochem. 2011 Aug;118(3):449-57. doi: 10.1111/j.1471-4159.2011.07307.x. Epub 2011 Jun 17

►Read More

Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis

Keller A, Leidinger P, Gislefoss R, Haugen A, Langseth H et al. (2011)

RNA Biol., Volume 8, Issue 3 May/June 2011

►Read More


Specific peripheral miRNA profiles for distinguishing lung cancer from COPD

Leidinger P, Keller A, Borries A, Huwer H, Rohling M et al. (2011)

Lung Cancer, 2011 Mar 7

►Read More

The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism

Shah A, Leidinger P, Keller A, Wendschlag A, Backes C et al. (2011)

RNA Biol., Volume 8, Issue 1, Pages 77–81, January/February 2011

►Read More

MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction

Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F et al. (2010)

Basic Research in Cardiology DOI: 10.1007/s00395-010-0123-2

►Read More

Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening

Häusler S, Keller A, Chandran A, Ziegler K, Zipp K, Heuer S et al. (2010)

British Journal of Cancer 103(5):693

►Read More

High-throughput miRNA profiling of human melanoma blood samples

Leidinger P, Keller A, Borries A, Reichrath J, Rass K et al. (2010)

BMC Cancer, 19:262

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Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application

Mraheil MA, Billion A, Kuenne C, Pischimarov J, Kreikemeyer B, et al. (2010)

Microbial Biotechnology, doi: 10.1111/j.1751-7915.2010.00171

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NcRNA-microchip analysis: A novel approach to identify differential expression of non-coding RNAs

Hutzinger R, Mrázek J, Vorwerk S and Huettenhofer A (2010)

RNA Biology 7(5)

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A dictionary on microRNAs and their putative target pathways

Backes C, Meese E, Lenhof HP and Keller A (2010)

Nucleic Acids Research 38(13): 4476-86

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Deciphering the porcine intestinal microRNA transcriptome

Sharbati S, Friedländer MR, Sharbati J, Hoeke L, Chen W, Keller A et al. (2010)

Biomed Central 11:275

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Circulating MicroRNAs in Patients With Coronary Artery Disease

Fichtlscherer, De Rosa S, Fox H, Schwietz T, Fischer A et al. (2010)

Circulation Research 107(5):677-84

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miRNAs in lung cancer – Studying complex fingerprints in patient’s blood cells by microarray experiments

Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F et al. (2009)

BMC Cancer 9:353

►Read More

Multiple Sclerosis – MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls

Keller A, Leidinger P, Lange J, Borries A, Schroers H et al. (2009)

PLoS ONE4(10):e7440

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Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis

Ke XS, Qu Y, Rostad K, Li WC, Lin B et al. (2009)

PLoS One 4(3):e4687.

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miRNA technology

Microfluidic-based enzymatic on-chip labeling of miRNAs

Vorwerk S, Ganter K, Cheng Y, Hoheisel J, Stähler PF and Beier M (2008)

New Biotechnology 25(2-3): 142-149

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Small Molecules with Big Impact in Cancer

Beier V, Hoheisel J (2008)

BIOforum Europe 12/2008

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Impact of MicroRNAs in Cancer Research

Beier V, Stähler PF (2008)

Whitepaper

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Other Application-Gene Expression Profiling

Heptahelical receptors GprC and GprD of Aspergillus fumigatus are essential regulators of colony growth, hyphal morphogenesis and virulence

Gehrke A, Heinekamp T, Jacobsen DI and Brakhage AA (2010)

Appl. Envir. Microbiol. 76(12):3989- 98

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Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W et al. (2009)

PNAS 106(34):14558-63

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Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing

Kristiansson E, Asker N, Forlin L and Larsson DG. (2009)

BMC Genomics 10(1):345

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A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysis

Keller A, Backes C, Gerasch A, Kaufmann M, Kohlbacher O et al. (2009)

Bioinformatics 25(21):2787-2794

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Pharmaceutical Industry Effluent Diluted 1:500 Affects Global Gene Expression, Cytochrome P4501A Activity and Plasma Phosphate in Fish

Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J et al. (2009)

Environ Toxicol Chem. 28(12):2639- 47

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Gene expression in Fusarium graminearum grown on plant cell wall

Carapito R, Hatsch D, Vorwerk S, Petkovski E, Jeltsch JM and Phalip V (2008)

Fungal Genet. Biol. 45(5): 738-748

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Transcription analysis using high-density micro- arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol

Mogensen J, Nielsen HB, Hofmann G and Nielsen J (2006)

Fungal Genet. Biol. 43(8): 593-603

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OligoWiz 2.0 – integrating sequence feature annotation into the design of microarray probes

Wernersson R and Nielsen HB (2005)

Nucleic Acids Res. 33: W611-615

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New weakly expressed cell cycle-regulated genes in yeast

de Lichtenberg U, Wernersson R, Jensen TS, Nielsen HB, Fausbøll A et al. (2005)

Yeast 22(15): 1191-1201

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Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodkin lymphoma cells

Relógio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C et al. (2005)

J. Biol. Chem. 280(6): 4779-4784

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Characterization of an Escherichia coli elaC deletion mutant

Schilling O, Rüggeberg S, Vogel A, Rittner N, Weichert S et al. (2004)

Biochem. Biophys. Res. Comm. 320(4): 1365-1373

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Validation of a novel, fully integrated and flexible microarray benchtop facility for gene expression profiling

Baum M, Bielau S, Rittner N, Schmid K, Eggelbusch K et al. (2003)

Nucleic Acids Res. 31: e151

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A flexible and fully integrated system for amplification, detection and genotyping of genomic DNA targets based on microfluidic oligonucleotide arrays

Summerer D, Hevroni D, Jain A, Oldenburger A, Parker J et al. (2008)

New Biotechnology 27 (2): 149-155

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Mit der Geniom-Microarray-Technologie HPV-Genotypen auf der Spur

Schliwka J, Pullat J, Devilliers EM, Hoheisel JD and Beier M (2007)

BIOspektrum 01.07

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Arrayed primer extension on in situ synthesized 5´-3´- oligonucleotides in microchannels

Pullat J, Kusnezow W, Jaakson K, Beier M, Hoheisel JD and Metspalu A (2008)

New Biotechnology 25 (2-3) :133-141

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Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples

Pullat J, Fleischer R, Becker N, Beier M, Metspalu A and Hoheisel JD (2007)

BMC Genomics 8: 282

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Other Application-Synthetic Biology

Another side of genomics: Synthetic biology as a mean for the exploitation of whole- genome sequence information

Stähler P, Beier M, Gao X and Hoheisel JD (2006)

J. Biotechnol. 124: 206-212

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Other Application-rRNA hybridization

Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predicted

Pozhitkoy A, Noble PA, Domazet-Lošo T, Nolte AW, Sonnenberg R et al. (2006)

Nucleic Acids Res. 34: e66

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Other Application-Epigenetic profiling

Array-based analysis of genomic DNA methylation patterns of the tumor suppressor gene p16INK4A promoter in colon carcinoma cell lines

Mund C, Beier V, Bewerunge P, Dahms M, Lyko F and Hoheisel JD (2005)

Nucleic Acids Res. 33(8): e73

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